The resting perfusion pattern associates with functional decline in type 2 diabetes

NEUROBIOLOGY OF AGING

卷:60

Article

Dai, Weiying¹  Duan, Wenna¹  Alfaro, Freddy J.²  Gavrieli, Anna²  Kourtelidis, Fotini³  Novak, Vera² 

[1] SUNY Binghamton, Dept Comp Sci, N-14,Engn Bldg, Binghamton, NY 13902 USA

[2] Harvard Med Sch, Dept Neurol, Beth Israel Deaconess Med Ctr, Boston, MA USA

[3] Harvard Med Sch, Dept Radiol, Beth Israel Deaconess Med Ctr, Boston, MA USA

关键词: Type 2 diabetes mellitus;    Cognitive impairment;    Cerebral blood flow;    Arterial spin labeling MRI;    Voxel-based analyses;    Insulin resistance;   

DOI  :  10.1016/j.neurobiolaging.2017.09.004

来源: Elsevier

【 摘 要 】

We investigated the relationships between cerebral blood flow (CBF), cognitive, and mobility decline in type 2 diabetes mellitus (T2DM) over a 2-year period. Seventy-three participants (41 T2DM and 32 controls) were evaluated using volumetric CBF with arterial spin labeling perfusion magnetic resonance imaging at baseline and at the 2-year follow-up. Regions with significant CBF differences between T2DM participants and controls at baseline were detected using voxel-wise analysis. Correlation analysis was performed to investigate the association between regional CBF and cognitive or mobility performance over the 2-year span. Compared to controls, participants with T2DM had decreased CBF in the resting-state default mode, visual, and cerebellum networks. Greater decrease in longitudinal CBF values at these regions over a 2-year span was associated with worse gait, memory and executive functions, and higher baseline insulin resistance and worse baseline cognitive performance. In T2DM, impairment of resting regional perfusion is closely related to worse cognitive and mobility performance. Insulin resistance may further contribute to regional perfusion deficit in T2DM. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

Free