Obesity is associated with reduced cerebral blood flow - modified by physical activity

NEUROBIOLOGY OF AGING

卷:105

Article

Knight, Silvin P.^1,2  Laird, Eamon^1,2  Williamson, Wilby^1,3  O'Connor, John^1,2  Newman, Louise^1,2  Carey, Daniel^1,2  De Looze, Celine^1,2  Fagan, Andrew J.⁴  Chappell, Michael A.^5,6  Meaney, James F.^2,7  Kenny, Rose Anne^1,2,3,8 

[1] Trinity Coll Dublin, Irish Longitudinal Study Ageing TILDA, Dublin, Ireland

[2] Trinity Coll Dublin, Sch Med, Dublin, Ireland

[3] Trinity Coll Dublin, Global Brain Hlth Inst GBHI, Dublin, Ireland

[4] Mayo Clin, Dept Radiol, Rochester, MN USA

[5] Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Oxford, England

[6] Univ Oxford, Inst Biomed Engn, Oxford, England

[7] St James Hosp, Natl Ctr Adv Med Imaging CAMI, Dublin, Ireland

[8] St James Hosp, Mercers Inst Successful Ageing MISA, Dublin, Ireland

关键词: Cerebral blood flow;    Obesity;    Physical activity;    Cerebral perfusion;    Arterial spin labeling MRI;   

DOI  :  10.1016/j.neurobiolaging.2021.04.008

来源: Elsevier

【 摘 要 】

This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM) in older adults. Cross-sectional data was used from the Irish Longitudinal Study on Ageing (n = 495, age 69.0 +/- 7.4 years, 52.1% female). Whole-brain CBFGM was quantified using arterial spin labeling MRI. Results from multivariable regression analysis revealed that an increase in BMI of 0.43 kg/m(2), WHR of 0.01, or WC of 1.3 cm were associated with the same reduction in CBFGM as 1 year of advancing age. Participants overweight by BMI or with high WHR/WC reporting low/moderate PA had up to 3 ml/100g/min lower CBFGM (p <= .011); there was no significant reduction for those reporting high PA. Since PA could potentially moderate obesity/CBF associations, this may be a cost-effective and relatively easy way to help mitigate the negative impact of obesity in an older population, such as cerebral hypoperfusion, which is an early mechanism in vascular dementia and Alzheimer's disease. (C) 2021 The Author(s). Published by Elsevier Inc.

【 授权许可】

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