Cerebral neurovascular alterations in stable chronic obstructive pulmonary disease: a preliminary fMRI study

PeerJ

article

Zhaohui Peng¹  Hong Tao Zhang³  Gang Wang⁴  Juntao Zhang⁵  Shaowen Qian⁶  Yajun Zhao⁷  Ruijie Zhang⁸  Wei Wang² 

[1] Department of Nuclear Medicine, Central Hospital affiliated to Shandong First Medical University;Department of Medical Imaging, Changzheng Hospital;Institute of Ophthalmology, Third Medical Center of PLA General Hospital;The Second Community Healthcare Service Center of Zhengzhou Road;GE Healthcare, Precision Health Institution;Department of Medical Imaging, Jinan Military General Hospital;Department of Medical Imaging, 71282 Hospital, Baoding, Hebei province;Department of Radiology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong Province

关键词: Cerebral blood flow;    Degree centrality;    Functional magnetic resonance;    Cognitive impairment;    Chronic obstructive pulmonary disease;   

DOI  :  10.7717/peerj.14249

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

PurposeCognitive impairment (CI) is very common in patients with chronic obstructive pulmonary disease (COPD). Cerebral structural and functional abnormalities have been reported in cognitively impaired patients with COPD, and the neurovascular coupling changes are rarely investigated. To address this issue, arterial spin labeling (ASL) and resting-state blood oxygenation level dependent (BOLD) fMRI techniques were used to determine whether any neurovascular changes in COPD patients.MethodsForty-five stable COPD patients and forty gender- and age-matched healthy controls were recruited. Furthermore, resting-state BOLD fMRI and ASL were acquired to calculate degree centrality (DC) and cerebral blood flow (CBF) respectively. The CBF-DC coupling and CBF/DC ratio were compared between the two groups.ResultsCOPD patients showed abnormal CBF, DC and CBF/DC ratio in several regions. Moreover, lower CBF/DC ratio in the left lingual gyrus negatively correlated with naming scores, lower CBF/DC ratio in medial frontal cortex/temporal gyrus positively correlated with the Montreal Cognitive Assessment (MoCA), visuospatial/executive and delayed recall scores.ConclusionThese findings may provide new potential insights into neuropathogenesis of cognition decline in stable COPD patients.

【 授权许可】

CC BY