Low-copper diet as a preventive strategy for Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:35

Review

Squitti, Rosanna^1,2  Siotto, Mariacristina³  Polimanti, Renato⁴ 

[1] San Giovanni Calibita Fatebenefratelli Hosp, Fatebenefratelli Fdn Hlth Res & Educ, AFaR Div, Rome, Italy

[2] IRCCS San Raffaele Pisana, Lab Neurodegeneraz, Rome, Italy

[3] Don Carlo Gnocchi Fdn ONLUS, Milan, Italy

[4] Univ Roma Tor Vergata, Dept Biol, I-00173 Rome, Italy

关键词: Copper;    Alzheimer's disease;    Diet;    Susceptibility;    Metabolism;    Genetics;    Prevention;    Food;    Drinking water;    Diet-gene interaction;   

DOI  :  10.1016/j.neurobiolaging.2014.02.031

来源: Elsevier

【 摘 要 】

Copper is an essential element, and either a copper deficiency or excess can be life threatening. Recent studies have indicated that alteration of copper metabolism is one of the pathogenetic mechanisms of Alzheimer's disease (AD). In light of these findings, many researchers have proposed preventive strategies to reduce AD risk. Because the general population comes in contact with copper mainly through dietary intake, that is, food 75% and drinking water 25%, a low-copper diet can reduce the risk of AD in individuals with an altered copper metabolism. We suggest that a diet-gene interplay is at the basis of the copper phenotype of sporadic AD. Herein, we describe the pathways regulating copper homeostasis, the adverse sequelae related to its derangements, the pathogenic mechanism of the AD copper phenotype, indications for a low-copper diet, and future perspectives to improve this preventive strategy. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free