Effect of short-term DHEA supplementation on serum and hippocampal estrogen concentrations in perimenopausal female rhesus macaques

NEUROBIOLOGY OF AGING

卷:55

Article

Urbanski, Henryk F.^1,2,3,4  Sorwell, Krystina G.^1,2  Prokai, Laszlo⁵  Kohama, Steven G.¹ 

[1] Oregon Natl Primate Res Ctr, Div Neurosci, 505 NW 185th Ave, Beaverton, OR 97006 USA

[2] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97210 USA

[4] Oregon Natl Primate Res Ctr, Div Reprod & Dev Sci, Beaverton, OR USA

[5] Univ North Texas, Hlth Sci Ctr, Inst Hlth Aging, Ctr Neurosci Discovery, Ft Worth, TX USA

关键词: Dehydroepiandrosterone;    Estradiol;    Estrone;    Hippocampus;    Menopause;   

DOI  :  10.1016/j.neurobiolaging.2017.03.026

来源: Elsevier

【 摘 要 】

The hippocampus of rhesus macaques expresses genes that encode key enzymes involved in the intracrine conversion of dehydroepiandrosterone (DHEA) to estradiol. Therefore, it is plausible that supplementary DHEA may enhance hippocampal estradiol concentrations and help to compensate for the marked postmenopausal attenuation of circulating estrogen levels. To test this hypothesis, we used LC-MS/MS to measure estradiol and estrone concentrations in the serum and hippocampus of young and old perimenopausal female rhesus macaques, as well as old perimenopausal females that received daily DHEA (5 mg) oral supplementation for 1 week. Despite lower concentrations of these estrogens in the serum of the older animals, their concentrations in the hippocampus did not show any obvious differences due to age or to DHEA supplementation. The results suggest that de novo estrogen synthesis in the brain may compensate for the perimenopausal loss of estrogens in the circulation even without supplemental DHEA. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

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