Sleep moderates the relationship between amyloid beta and memory recall

NEUROBIOLOGY OF AGING

卷:71

Article

Wilckens, Kristine A.¹  Tudorascu, Dana L.²  Snitz, Beth E.³  Price, Julie C.^4,5  Aizenstein, Howard J.¹  Lopez, Oscar L.³  Erickson, Kirk I.⁶  Lopresti, Brian J.⁴  Laymon, Charles M.^4,7  Minhas, Davneet⁴  Mathis, Chester A.⁴  Buysse, Daniel J.¹  Klunk, William E.^1,2  Cohen, Ann D.¹ 

[1] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[2] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

[4] Univ Pittsburgh, Sch Med, Dept Radiol, Pittsburgh, PA USA

[5] Massachusetts Gen Hosp, AA Martinos Ctr Biomed Imaging, Charlestown, MA USA

[6] Univ Pittsburgh, Sch Med, Dept Psychol, Pittsburgh, PA USA

[7] Univ Pittsburgh, Sch Med, Dept Bioengn, Pittsburgh, PA USA

关键词: Amyloid-beta;    Sleep;    Neuropsychological performance;    Mild cognitive impairment;    Preclinical Alzheimer's disease;   

DOI  :  10.1016/j.neurobiolaging.2018.07.011

来源: Elsevier

【 摘 要 】

Amyloid-beta (Ab) accumulation is a hallmark of Alzheimer's disease, although Ab alone may be insufficient to cause impairments. Modifiable health factors, including sleep, may mitigate functional symptoms of neurodegeneration. We assessed whether sleep moderated the relationship between Ab and cognitive performance in 41 older adults, mean age 83 years. Sleep measures included actigraphy-assessed wake after sleep onset and total sleep time. Cognitive performance was assessed with memory recall, cognitive flexibility, and verbal fluency. Memory recall was assessed with the Rey-Osterrieth Complex Figure task, cognitive flexibility with the Trail Making test, and verbal fluency with FAS word generation. Ab was assessed with a global measure of Pittsburgh Compound B. Wake after sleep onset moderated the relationship between Ab and memory, with a stronger positive association for Ab and forgetting in those with poorer sleep. These results suggest a possible protective role of sleep in preclinical Alzheimer's disease. (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

Free