Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome

NEUROBIOLOGY OF AGING

卷:58

Article

Hartley, Sigan L.^1,2  Handen, Benjamin L.^3,4  Devenny, Darlynne⁵  Mihaila, Iulia^1,2  Hardison, Regina⁶  Lao, Patrick J.^2,7  Klunk, William E.^3,8  Bulova, Peter³  Johnson, Sterling C.^9,10  Christian, Bradley T.^2,7 

[1] Univ Wisconsin, Dept Human Dev & Family Studies, Madison, WI USA

[2] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA

[3] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[4] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[5] New York State Inst Basic Res Dev Disabil, Albany, NY USA

[6] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA

[7] Univ Wisconsin, Dept Med Phys, 1530 Med Sci Ctr, Madison, WI 53706 USA

[8] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[9] Univ Wisconsin, Dept Med, Madison, WI USA

[10] Wisconsin Alzheimers Dis Res Ctr, Madison, WI USA

关键词: Alzheimer's disease;    Dementia;    Down syndrome;    Amyloid-beta;    PiB;    Mild cognitive impairment;   

DOI  :  10.1016/j.neurobiolaging.2017.05.019

来源: Elsevier

【 摘 要 】

Adults with Down syndrome (DS) have a high incidence of Alzheimer's disease (AD), providing a unique opportunity to explore the early, preclinical stages of AD neuropathology. We examined change in brain amyloid-beta accumulation via the positron emission tomography tracer [11C] Pittsburgh compound B (PiB) across 2 data collection cycles, spaced 3 years apart, and decline in cognitive functioning in 58 adults with DS without clinical AD. PiB retention increased in the anterior cingulate gyrus, precuneus cortex, parietal cortex, and anterior ventral striatum. Across the 2 cycles, 14 (27.5%) participants were consistently PiB+, 31 (60.8%) were consistently PiB, and 6 (11.7%) converted from PiB at cycle 1 to PiB+ at cycle 2. Increased global amyloid-beta was related to decline in verbal episodic memory, visual episodic memory, executive functioning, and fine motor processing speed. Participants who were consistently PiB+ demonstrated worsening of episodic memory, whereas participants who were consistently PiB evidenced stable or improved performance. Amyloid-beta accumulation may be a contributor to or biomarker of declining cognitive functioning in preclinical AD in DS. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

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