Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:33

Article

Yezhuvath, Uma S.¹  Uh, Jinsoo¹  Cheng, Yamei¹  Martin-Cook, Kristin²  Weiner, Myron²  Diaz-Arrastia, Ramon²  van Osch, Matthias³  Lu, Hanzhang¹ 

[1] Univ Texas SW Med Ctr Dallas, Adv Imaging Res Ctr, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Alzheimers Dis Ctr, Dallas, TX 75390 USA

[3] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands

关键词: Alzheimer's disease;    Cerebral blood flow;    Cerebrovascular reactivity;    Magnetic resonance imaging;    Vascular function;   

DOI  :  10.1016/j.neurobiolaging.2010.02.005

来源: Elsevier

【 摘 要 】

Epidemiologic evidence and postmortem studies of cerebral amyloid angiopathy suggest that vascular dysfunction may play an important role in the pathogenesis of Alzheimer's disease (AD). However, alterations in vascular function under in vivo conditions are poorly understood. In this study, we assessed cerebrovascular-reactivity (CVR) in AD patients and age-matched controls using CO2-inhalation while simultaneously acquiring Blood-Oxygenation-Level-Dependent (BOLD) MR images. Compared with controls, AD patients had widespread reduction in CVR in the rostral brain including prefrontal, anterior cingulate, and insular cortex (p < 0.01). The deficits could not be explained by cardiovascular risk factors. The spatial distribution of the CVR deficits differed drastically from the regions of cerebral blood flow (CBF) deficits, which were found in temporal and parietal cortices. Individuals with greater CVR deficit tended to have a greater volume of leukoaraiosis as seen on FLAIR MRI (p = 0.004). Our data suggest that early AD subjects have evidence of significant forebrain vascular contractility deficits. The localization, while differing from CBF findings, appears to be spatially similar to PIB amyloid imaging findings. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

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