Total glutamine synthetase levels in cerebrospinal fluid of Alzheimer's disease patients are unchanged

NEUROBIOLOGY OF AGING

卷:36

Article

Timmer, Nienke M.^1,2  Herbert, Megan K.^1,2  Claassen, Jurgen A. H. R.³  Kuiperij, H. Bea^1,2  Verbeek, Marcel M.^1,2 

[1] Radboud Univ Nijmegen, Med Ctr, Radboud Alzheimer Ctr, Dept Neurol,Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Radboud Alzheimer Ctr, Dept Geriatr Med, NL-6500 HB Nijmegen, Netherlands

关键词: Glutamine synthetase;    Cerebrospinal fluid;    Alzheimer's disease;    Dementia with Lewy bodies;    Frontotemporal dementia;   

DOI  :  10.1016/j.neurobiolaging.2014.12.010

来源: Elsevier

【 摘 要 】

Decreased cerebral protein and activity levels of glutamine synthetase (GS) have been reported for Alzheimer's disease (AD) patients. Using a recently established method, we quantified total GS levels in cerebrospinal fluid (CSF) from AD patients and control subjects. Furthermore, we investigated if total GS levels in CSF could differentiate AD from frontotemperal dementia and dementia with Lewy bodies patients. As we found no significantly altered total GS levels in any of the patient groups compared with control subjects, we conclude that levels of total GS in CSF have no diagnostic value for AD, dementia with Lewy bodies, or frontotemperal dementia. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

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