Brain tissue properties link cardio-vascular risk factors, mood and cognitive performance in the CoLaus|PsyCoLaus epidemiological cohort

NEUROBIOLOGY OF AGING

卷:102

Article

Trofimova, Olga^1,2  Loued-Khenissi, Leyla^1,2  DiDomenicantonio, Giulia^1,2  Lutti, Antoine^1,2  Kliegel, Matthias⁴  Stringhini, Silvia^5,6  Marques-Vidal, Pedro^2,3  Vollenweider, Peter^2,3  Waeber, Gerard^2,3  Preisig, Martin^2,7  Kherif, Ferath^1,2  Draganski, Bogdan^1,2,8 

[1] Lausanne Univ Hosp, Dept Clin Neurosci, Ctr Res Neurosci, Lab Res Neuroimaging LREN, Mont Paisible 16, CH-1011 Lausanne, Switzerland

[2] Univ Lausanne, Mont Paisible 16, CH-1011 Lausanne, Switzerland

[3] Lausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland

[4] Univ Geneva, Dept Psychol, Geneva, Switzerland

[5] Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland

[6] Lausanne Univ Hosp, Inst Social & Prevent Med, Lausanne, Switzerland

[7] Lausanne Univ Hosp, Dept Psychiat, Ctr Res Psychiat Epidemiol & Psychopathol, Lausanne, Switzerland

[8] Max Planck Inst Human Cognit & Brain Sci, Neurol Dept, Leipzig, Germany

关键词: Aging;    Cardiovascular disease;    Cognition;    Major depressive disorder;    Quantitative magnetic resonance imaging;   

DOI  :  10.1016/j.neurobiolaging.2021.02.002

来源: Elsevier

【 摘 要 】

Given the controversy about the impact of modifiable risk factors on mood and cognition in ageing, we sought to investigate the associations between cardio-vascular risk, mental health, cognitive performance and brain anatomy in mid-to old age. We analyzed a set of risk factors together with multi-parameter magnetic resonance imaging (MRI) in the CoLaus|PsyCoLaus cohort (n > 1200). Cardio-vascular risk was associated with differences in brain tissue properties - myelin, free tissue water, iron content - and re-gional brain volumes that we interpret in the context of micro-vascular hypoxic lesions and neurode-generation. The interaction between clinical subtypes of major depressive disorder and cardio-vascular risk factors showed differential associations with brain structure depending on individuals' lifetime tra-jectory. There was a negative correlation between melancholic depression, anxiety and MRI markers of myelin and iron content in the hippocampus and anterior cingulate. Verbal memory and verbal fluency performance were positively correlated with left amygdala volumes. The concomitant analysis of brain morphometry and tissue properties allowed for a neuro-biological interpretation of the link between modifiable risk factors and brain health. (c) 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

【 授权许可】

Free