Associations between symptoms of depression and heart rate variability: An exploratory study

PSYCHIATRY RESEARCH

卷:262

Article

Borrione, Lucas¹  Brunoni, Andre R.²  Sampaio-Junior, Bernardo^1,4  Aparicio, Luana M.¹  Kemp, Andrew H.^1,3  Bensenor, Isabela¹  Lotufo, Paulo A.¹  Fraguas, Renerio^1,5 

[1] Univ Sao Paulo, Hosp Univ, Clin & Epidemiol Res Ctr, Ave Prof Lineu Prestes 2565, BR-05508000 Sao Paulo, SP, Brazil

[2] Inst Psiquiatria HC FMUSP, Lab Neurosci LIM27, Serv Interdisciplinary Neuromodulat, Rua Dr Ovidio Pires Campos 785, BR-01060970 Sao Paulo, SP, Brazil

[3] Univ Swansea, Dept Psychol, Singleton Pk, Swansea SA2 8PP, W Glam, Wales

[4] HC FMUSP, Dept & Inst Psychiat, Rua Dr Ovidio Pires Campos 785, BR-01060970 Sao Paulo, SP, Brazil

[5] HC FMUSP, Dept & Inst Psychiat, Lab Psychiat Neuroimaging LIM21, Rua Dr Ovidio Pires Campos 785, BR-01060970 Sao Paulo, SP, Brazil

关键词: Depressive symptoms;    Major depressive disorder;    Heart rate;    Melancholic features;    Melancholia;    Cardiovascular disease;   

DOI  :  10.1016/j.psychres.2017.09.028

来源: Elsevier

【 摘 要 】

Major depressive disorder (MDD) is associated with decreased heart rate variability (HRV), a predictor of cardiovascular morbidity by many, but not all studies. This inconsistency could be due to the association of HRV with specific depressive symptoms. Here, we investigated the association of HRV parameters with components of depressive symptoms from 120 MDD patients, at baseline of a published trial comparing the effect of sertraline to transcranial direct current stimulation. We used Principal Component Analysis to extract components of the Hamilton Rating Scale for Depression (HAM-D-17), the Montgomery Asberg Depression Rating Scale (MADRS) and the Beck Inventory for Depressive Symptomatology (BDI). We constructed one equation of multiple linear regression for each HRV parameter as the dependent variable, and the components of depressive symptoms of the three scales as the independent ones, adjusted for age and gender. A component of HAM-D-17 predicted LF/HF (low frequency/high frequency) and a component of MADRS predicted LF (low frequency). Guilt and loss of interest/pleasure in activities were present in the components of both scales, and the MADRS component also included psychomotor retardation. These results suggest that melancholic features might be relevant for the association between MDD and HRV. Considering multiple comparisons, these results are preliminary.

【 授权许可】

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