Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment

NEUROBIOLOGY OF AGING

卷:31

Article

Smith, Charles D.^2,4,5,6  Schmitt, Fred A.^2,3  Gold, Brian T.^1,6 

[1] Univ Kentucky, Sch Med, Dept Anat & Neurobiol, Chandler Med Ctr, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Neurol, Chandler Med Ctr, Lexington, KY 40536 USA

[3] Univ Kentucky, Dept Psychiat, Chandler Med Ctr, Lexington, KY 40536 USA

[4] Univ Kentucky, Alzheimers Dis Ctr, Chandler Med Ctr, Lexington, KY 40536 USA

[5] Univ Kentucky, Brown Ctr Aging, Chandler Med Ctr, Lexington, KY 40536 USA

[6] Univ Kentucky, Magnet Resonance Imaging & Spect Ctr, Chandler Med Ctr, Lexington, KY 40536 USA

关键词: MCI;    Aging;    Structural MRI;    Hippocampus;    ERC;   

DOI  :  10.1016/j.neurobiolaging.2008.08.010

来源: Elsevier

【 摘 要 】

The present study sought to determine if volumes of specific brain structures could discriminate cognitively normal seniors destined to develop mild cognitive impairment (MCI) within a few years from those who will remain normal. Brain scans were collected from seventy-one cognitively normal seniors. Seventeen individuals later developed MCI (the presymptomatic MCI; pMCI group), while fifty-four remained normal. Whole brain volume (WBV) and volumes of the entorhinal cortex (ERC), hippocampus, and three subregions of the hippocampus (head; HH, body; FIB and tail; HT) were compared. Results indicated that the pMCI group had smaller volumes than the normal group in the ERC, HH and HB, but not the HT or WBV. When HH/HB volumes and baseline memory test scores were included in a single logistic regression model, classification accuracy was very high (area under the curve = 0.93). These results show that smaller normalized volumes of anterior medial temporal lobe structures contribute to the development of MCI, a finding which may have implications for identifying seniors at risk for cognitive decline. (C) 2008 Elsevier Inc. All rights reserved.

【 授权许可】

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