Parahippocampal white matter volume predicts Alzheimer's disease risk in cognitively normal old adults

NEUROBIOLOGY OF AGING

卷:35

Article

Stoub, Travis R.¹  deToledo-Morrell, Leyla¹  Dickerson, Bradford C.² 

[1] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA USA

关键词: Imaging;    Aging;    Perforant pathway;    Hippocampus;    Entorhinal cortex;    Structural MRI;   

DOI  :  10.1016/j.neurobiolaging.2014.01.153

来源: Elsevier

【 摘 要 】

An in vivo marker of the underlying pathology in Alzheimer's disease (AD) is atrophy in select brain regions detected with quantitative magnetic resonance imaging (MRI). Although gray matter changes have been documented to be predictive of cognitive decline culminating in AD among healthy older adults, very little attention has been given to alterations in white matter as a possible MRI biomarker predictive of AD. In this investigation, we examined parahippocampal white matter (PWM) volume derived from baseline MRI scans in 2 independent samples of 65 cognitively normal older adults, followed longitudinally, to determine if it was predictive of AD risk. The average follow-up period for the 2 samples was 8.5 years. Comparisons between the stable participants (N = 50) and those who declined to AD (N = 15) over time revealed a significant difference in baseline PWM volume (p < 0.001). Furthermore, baseline PWM volume was predictive not only of time to AD (hazard ratio 3.1, p < 0.05), but also of baseline episodic memory performance (p = 0.041). These results demonstrate that PWM atrophy provides a sensitive MRI biomarker of AD dementia risk among those with normal cognitive function. (c) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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