Evolution of brain atrophy subtypes during aging predicts long-term cognitive decline and future Alzheimer's clinical syndrome

NEUROBIOLOGY OF AGING

卷:79

Article

Planche, Vincent^1,2  Coupe, Pierrick³  Helmer, Catherine⁴  Le Goff, Melanie⁴  Amieva, Helene⁴  Tison, Francois^1,2  Dartigues, Jean-Francois^2,4  Catheline, Gwenaelle^5,6 

[1] Univ Bordeaux, CNRS, UMR, Inst Malad Neurodegenerat, Bordeaux, France

[2] CHU Bordeaux, Ctr Memoire Ressources & Rech, Pole Neurosci Clin, Bordeaux, France

[3] Univ Bordeaux, CNRS, UMR 5800, Lab Bordelais Rech Informat, Talence, France

[4] Univ Bordeaux, Inserm, UMR 1219, Bordeaux Populat Hlth Res Ctr, Bordeaux, France

[5] EPHE, PSL, Bordeaux, France

[6] Univ Bordeaux, CNRS, UMR 5287, Inst Neurosci Cognit & Integrat Aquitaine, Bordeaux, France

关键词: Hippocampus;    Cortex;    Imaging;    Alzheimer;    Aging;    Cohort study;   

DOI  :  10.1016/j.neurobiolaging.2019.03.006

来源: Elsevier

【 摘 要 】

It is currently unknown whether brain atrophy subtypes defined in Alzheimer's disease are clinically relevant during aging. We investigated participants (n = 368) from a population-based cohort of non-demented older adults who received longitudinal neuropsychological assessments during 12 years. Magnetic resonance imaging scans at baseline and 4 years later were used to define participants with hippocampal predominant atrophy, cortical predominant atrophy, homogenous atrophy, and no evidence of brain subtype atrophy based on the dynamics of hippocampal-to-cortical volume ratio evolution. After adjustment on age, gender, educational level, and ApoE4 genotype, participants with hippocampal predominant atrophy declined faster regarding global cognition, verbal fluency, and verbal episodic memory. In Cox proportional-hazards models, hippocampal predominant atrophy was associated with an increased risk of developing Alzheimer's clinical syndrome over time (hazard ratio = 5.73; 95% CI 2.71-12.15), independently of age and ApoE4 genotype, the 2 other significant predictive factors. As a possible surrogate of confined tauopathy and early Alzheimer's disease pathology, future studies should consider the definition of hippocampal predominant atrophy based on hippocampal-tocortical volume ratio evolution rather than hippocampal volume alone. (C) 2019 Elsevier Inc. All rights reserved.

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