Using stem cell-derived neurons in drug screening for neurological diseases

NEUROBIOLOGY OF AGING

卷:78

Review

Little, Daniel¹  Ketteler, Robin¹  Gissen, Paul¹  Devine, Michael J.^1,2 

[1] UCL, MRC Lab Mol Cell Biol, London, England

[2] UCL, Dept Neurosci Physiol & Pharmacol, London, England

关键词: Induced pluripotent stem cells;    Embryonic stem cells;    Drug screening;    Drug discovery;    High content screening;    Neurodegeneration;    Parkinson's disease;    Alzheimer's disease;    Motor neuron disease;    Huntington's disease;   

DOI  :  10.1016/j.neurobiolaging.2019.02.008

来源: Elsevier

【 摘 要 】

Induced pluripotent stem cells and their derivatives have become an important tool for researching disease mechanisms. It is hoped that they could be used to discover new therapies by providing the most reliable and relevant human in vitro disease models for drug discovery. This review will summarize recent efforts to use stem cell-derived neurons for drug screening. We also explain the current hurdles to using these cells for high-throughput pharmaceutical screening and developments that may help overcome these hurdles. Finally, we critically discuss whether induced pluripotent stem cell-derived neurons will come to fruition as a model that is regularly used to screen for drugs to treat neurological diseases. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

Free