Clinical potentials of human pluripotent stem cells in lung diseases

Clinical and Translational Medicine

Yuan Quan¹  Dachun Wang¹ 

[1] The Brown Foundation Institute of Molecular Medicine for the prevention of Human DiseasesUniversity of Texas Medical School at Houston1825 Pressler Street/IMM 437D77030HoustonTXUSA;

关键词: Induced pluripotent stem cells;    Embryonic stem cells;    Differentiation and characterization;    Lung stem/progenitor cells;    and Lung tissue engineering;   

DOI  :  10.1186/2001-1326-3-15

来源: DOAJ

【 摘 要 】

Abstract Lung possesses very limited regenerative capacity. Failure to maintain homeostasis of lung epithelial cell populations has been implicated in the development of many life‐threatening pulmonary diseases leading to substantial morbidity and mortality worldwide, and currently there is no known cure for these end‐stage pulmonary diseases. Embryonic stem cells (ESCs) and somatic cell‐derived induced pluripotent stem cells (iPSCs) possess unlimited self‐renewal capacity and great potential to differentiate to various cell types of three embryonic germ layers (ectodermal, mesodermal, and endodermal). Therapeutic use of human ESC/iPSC‐derived lung progenitor cells for regeneration of injured or diseased lungs will have an enormous clinical impact. This article provides an overview of recent advances in research on pluripotent stem cells in lung tissue regeneration and discusses technical challenges that must be overcome for their clinical applications in the future.

【 授权许可】

Unknown