APOE-epsilon4 and aging of medial temporal lobe gray matter in healthy adults older than 50 years

NEUROBIOLOGY OF AGING

卷:35

Article

Taylor, Joy L.^1,2  Scanlon, Blake K.^1,2  Farrell, Michelle^1,2  Hernandez, Beatriz^1,2  Adamson, Maheen M.^1,2  Ashford, J. Wesson^1,2  Noda, Art^1,2  Murphy, Greer M., Jr.²  Weiner, Michael W.^3,4 

[1] Sierra Pacific MIRECC, Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

[2] Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA

[3] Ctr Imaging Neurodegenerat Dis, Dept Vet Affairs Med Ctr, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA

关键词: Aging;    Apolipoprotein E4;    Alzheimer's disease;    Brain-derived neurotrophic factor;    Hippocampus;    Longitudinal studies;    Magnetic resonance imaging;   

DOI  :  10.1016/j.neurobiolaging.2014.05.011

来源: Elsevier

【 摘 要 】

Atrophy of the hippocampus and surrounding temporal regions occurs in Alzheimer's disease (AD). APOE epsilon 4, the major genetic risk factor for late-onset AD, has been associated with smaller volume in these regions before amyloidosis can be detected by AD biomarkers. To examine APOE epsilon 4 effects in relation to aging, we performed a longitudinal magnetic resonance imaging study involving cognitively normal adults (25 APOE epsilon 4 carriers and 31 epsilon 3 homozygotes), initially aged 51-75 years. We used growth curve analyses, which can provide information about APOE epsilon 4-related differences initially and later in life. Hippocampal volume was the primary outcome; nearby medial temporal regions were secondary outcomes. Brain-derived neurotrophic factor, val66met was a secondary covariate. APOE epsilon 4 carriers had significantly smaller initial hippocampal volumes than epsilon 3 homozygotes. Rate of hippocampal atrophy was not greater in the APOE epsilon 4 group, although age-related atrophy was detected in the overall sample. The findings add to the growing evidence that effects of APOE epsilon 4 on hippocampal size begin early in life, underscoring the importance of early interventions to increase reserve. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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