Is there a specific memory signature associated with Aβ-PET positivity in patients with amnestic mild cognitive impairment?

NEUROBIOLOGY OF AGING

卷:77

Article

Tomadesso, Clemence^1,2  Gonneaud, Julie¹  Egret, Stephanie¹  Perrotin, Audrey¹  Pelerin, Alice²  de Flores, Robin¹  de la Sayette, Vincent³  Desgranges, Beatrice²  Chetelat, Gael¹  La Joie, Renaud^1,4 

[1] Univ Caen Normandie, GIP Cyceron, Inserm UMR S U1237, INSERM, Caen, France

[2] PSL Univ Paris, Normandie Univ, CHU Caen, UNICAEN,EPHE,Inserm,U1077, Caen, France

[3] CHU Caen, Serv Neurol, Caen, France

[4] Univ Calif San Francisco, Memoty & Aging Ctr, Dept Neurol, San Francisco, CA USA

关键词: Alzheimer's disease;    Amnestic mild cognitive impairment;    Beta amyloid;    Positron emission tomography;    Hippocampus;    Memory;   

DOI  :  10.1016/j.neurobiolaging.2019.01.017

来源: Elsevier

【 摘 要 】

Amnestic mild cognitive impairment (aMCI) is a clinical entity with various potential etiologies including but not limited to Alzheimer's disease. We examined whether a positive ([18F]Florbetapir) beta amyloid positron emission tomography scan, supporting underlying Alzheimer's disease pathophysiology, was associated with specific memory deficits in 48 patients with aMCI (33 beta amyloid positive, 15 beta amyloid negative). Memory was evaluated using an autobiographical fluency task and a word-list learning task with 2 different encoding types (shallow/incidental versus deep/intentional). Compared with 40 beta amyloid-negative controls, both aMCI subgroups demonstrated severe deficits in the global memory score and in most subscores of both tasks. Finer-grained analyses of memory tests showed subtle association with beta amyloid status, revealing a stronger impairment of the primacy effect in beta amyloid-positive patients. Structural magnetic resonance imaging showed that both aMCI subgroups exhibited comparable atrophy patterns, with similar degrees of medial temporal volume loss compared with controls. Specifically assessing the primacy effect might complement global memory scores in identifying beta amyloid-positive patients with aMCI. (C) 2019 Elsevier Inc. All rights reserved.

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