Association between Toxoplasma gondii seropositivity and memory function in nondemented older adults

NEUROBIOLOGY OF AGING

卷:53

Article

Wyman, Cynthia P.¹  Gale, Shawn D.^1,2  Hedges-Muncy, Ariana¹  Erickson, Lance D.³  Wilson, Eric⁴  Hedges, Dawson W.^1,2 

[1] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA

[2] Brigham Young Univ, Neurosci Ctr, 1060 SWKT, Provo, UT 84602 USA

[3] Brigham Young Univ, Dept Sociol, Provo, UT 84602 USA

[4] Brigham Young Univ, Dept Microbiol & Mol Biol, Provo, UT 84602 USA

关键词: Toxoplasma gondii;    Toxoplasmosis;    Neurocognitive function;    Aging;    Memory;   

DOI  :  10.1016/j.neurobiolaging.2017.01.018

来源: Elsevier

【 摘 要 】

Toxoplasma gondii (T. gondii) seropositivity may be associated with decreased memory in older adults. To further investigate the association between T. gondii seropositivity and memory in nondemented older adults, we obtained serum samples from 114 nondemented older adults evaluated by the Alzheimer's Disease and Research Center at Washington University in St. Louis, Missouri, USA. We determined T. gondii seropositivity and anti-T. gondii IgG antibody titer and examined associations with memory function while controlling for socioeconomic status, education level, age, and apolipoprotein E4 status. There were few associations between T. gondii seropositivity or anti-T. gondii IgG antibodies and memory, although there was some support suggesting an interaction between anti-T. gondii and sex. In the seropositive-only sample, there was an inverse relationship between anti-T. gondii titer and performance on the selective reminding test. Overall, we found little evidence of an association between impaired memory function and T. gondii seropositivity and anti-T. gondii IgG antibodies in this sample of nondemented older adults. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

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