Resting state functional connectivity alterations in primary lateral sclerosis

NEUROBIOLOGY OF AGING

卷:35

Article

Agosta, Federica¹  Canu, Elisa¹  Inuggi, Alberto¹  Riva, Nilo²  Silani, Vincenzo^5,6,7  Calvo, Andrea⁴  Messina, Stefano^5,6,7  Falini, Andrea³  Comi, Giancarlo²  Filippi, Massimo^1,2 

[1] Univ Vita Salute San Raffaele, Neuroimaging Res Unit, Inst Expt Neurol, San Raffaele Sci Inst,Div Neurosci, Milan, Italy

[2] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Dept Neurol, Milan, Italy

[3] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, CERMAC, Dept Neuroradiol, Milan, Italy

[4] Univ Turin, Rita Levi Montalcini Dept Neurosci, Turin, Italy

[5] IRCCS Ist Auxol Italiano, Dept Neurol, Milan, Italy

[6] IRCCS Ist Auxol Italiano, Lab Neurosci, Milan, Italy

[7] Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy

关键词: Primary lateral sclerosis;    Resting state functional MRI;    Functional connectivity;    Sensorimotor network;    Diffusion tensor MRI tractography;   

DOI  :  10.1016/j.neurobiolaging.2013.09.041

来源: Elsevier

【 摘 要 】

Resting state functional connectivity of the sensorimotor and extramotor brain networks was studied in 24 patients with primary lateral sclerosis (PLS) relative to 26 healthy controls. The relationships of RS functional connectivity with patient clinical and cognitive status and white matter tract damage (i.e., corticospinal tracts, corpus callosum, and superior longitudinal fasciculus) were investigated. Compared with controls, PLS patients showed an increased functional connectivity within the sensorimotor, frontal, and left frontoparietal networks spanning the pre-and postcentral, medial and dorsal frontal, insular, and superior temporal regions. Patients with more severe physical disability and a more rapid rate of disease progression had increased sensorimotor connectivity values. The increased functional connectivity within the frontal network was associated with executive dysfunction. In addition, higher functional connectivity correlated with greater structural damage to network-specific white matter tracts. This study shows clinically meaningful increased resting state functional connectivity in PLS. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free