A preliminary study of functional connectivity in comorbid adolescent depression

NEUROSCIENCE LETTERS

卷:460

Article

Cullen, Kathryn R.¹  Gee, Dylan G.³  Klimes-Dougan, Bonnie¹  Gabbay, Vilma^3,4  Hulvershorn, Leslie³  Mueller, Bryon A.¹  Camchong, Jamin¹  Bell, Christopher J.¹  Houri, Alaa¹  Kumra, Sanjiv¹  Lim, Kelvin O.^1,2  Castellanos, F. Xavier^3,4  Milham, Michael P.³ 

[1] Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA

[2] Vet Adm Med Ctr, Minneapolis, MN 55417 USA

[3] NYU, Sch Med, Dept Child & Adolescent Psychiat, New York Child Study Ctr, New York, NY USA

[4] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA

关键词: Adolescence;    Brain imaging;    Depression;    Functional connectivity;    Resting state functional MRI;    Subgenual anterior cingulate cortex;   

DOI  :  10.1016/j.neulet.2009.05.022

来源: Elsevier

【 摘 要 】

Major depressive disorder (MDD) begins frequently in adolescence and is associated with severe outcomes, but the developmental neurobiology of MDD is not well understood. Research in adults has implicated fronto-limbic neural networks in the pathophysiology of MDD, particularly in relation to the subgenual anterior cingulate cortex (ACC). Developmental changes in brain networks during adolescence highlight the need to examine MDD-related circuitry in teens separately from adults. Using resting state functional magnetic resonance imaging (fMRI), this study examined functional connectivity in adolescents with MDD (n = 12) and healthy adolescents (n = 14). Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). These preliminary data suggest that MDD in adolescence is associated with abnormal connectivity within neural circuits that mediate emotion processing. Future research in larger, un-medicated samples will be necessary to confirm this finding. We conclude that hypothesis-driven, seed-based analyses of resting state fMRI data hold promise for advancing our current understanding of abnormal development of neural circuitry in adolescents with MDD. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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