Complex functional brain network properties in anorexia nervosa

Journal of Eating Disorders

Alannah Rivera-Cancel¹  Nancy Zucker²  John L. Graner³  Kevin S. LaBar³  Philip A. Kragel⁴  Thomas Rodriguez⁵  Kareem Hamadani⁵  Priten Vora⁵  Rishi Makkar⁵  Anita Alaverdyan⁵  Bruce Naliboff⁶  Arpana Gupta⁶  Jennifer S. Labus⁶  Emeran A. Mayer⁷  Ravi R. Bhatt⁸ 

[1] Department of Psychiatry and Behavioral Sciences, Duke University, Durham, USA;Department of Psychiatry and Behavioral Sciences, Duke University, Durham, USA;Department of Psychology and Neuroscience, Duke University, Durham, USA;Department of Psychology and Neuroscience, Duke University, Durham, USA;Department of Psychology, Emory University, Atlanta, USA;G. Oppenheimer Center for Neurobiology of Stress and Resilience, UCLA, 90095, Los Angeles, CA, USA;G. Oppenheimer Center for Neurobiology of Stress and Resilience, UCLA, 90095, Los Angeles, CA, USA;David Geffen School of Medicine, UCLA, 90095, Los Angeles, CA, USA;Vatche and Tamar Manoukian Division of Digestive Diseases, UCLA, 90095, Los Angeles, CA, USA;G. Oppenheimer Center for Neurobiology of Stress and Resilience, UCLA, 90095, Los Angeles, CA, USA;David Geffen School of Medicine, UCLA, 90095, Los Angeles, CA, USA;Vatche and Tamar Manoukian Division of Digestive Diseases, UCLA, 90095, Los Angeles, CA, USA;Ahmanson-Lovelace Brain Mapping Center, UCLA, 90095, Los Angeles, CA, USA;G. Oppenheimer Center for Neurobiology of Stress and Resilience, UCLA, 90095, Los Angeles, CA, USA;Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine at USC, University of Southern California, Los Angeles, USA;

关键词: Anorexia nervosa;    Network metrics;    Sensorimotor network;    Basal ganglia;    Functional connectivity;   

DOI  :  10.1186/s40337-022-00534-9

来源: Springer

【 摘 要 】

BackgroundAnorexia nervosa (AN) is a disorder characterized by an incapacitating fear of weight gain and by a disturbance in the way the body is experienced, facets that motivate dangerous weight loss behaviors. Multimodal neuroimaging studies highlight atypical neural activity in brain networks involved in interoceptive awareness and reward processing.MethodsThe current study used resting-state neuroimaging to model the architecture of large-scale functional brain networks and characterize network properties of individual brain regions to clinical measures. Resting-state neuroimaging was conducted in 62 adolescents, 22 (21 female) with a history of AN and 40 (39 female) healthy controls (HCs). Sensorimotor and basal ganglia regions, as part of a 165-region whole-brain network, were investigated. Subject-specific functional brain networks were computed to index centrality. A contrast analysis within the general linear model covarying for age was performed. Correlations between network properties and behavioral measures were conducted (significance q < .05).ResultsCompared to HCs, AN had lower connectivity from sensorimotor regions, and greater connectivity from the left caudate nucleus to the right postcentral gyrus. AN demonstrated lower sensorimotor centrality, but higher basal ganglia centrality. Sensorimotor connectivity dyads and centrality exhibited negative correlations with body dissatisfaction and drive for thinness, two essential features of AN.ConclusionsThese findings suggest that AN is associated with greater communication from the basal ganglia, and lower information propagation in sensorimotor cortices. This is consistent with the clinical presentation of AN, where individuals exhibit patterns of rigid habitual behavior that is not responsive to bodily needs, and seem “disconnected” from their bodies.

【 授权许可】

CC BY