Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification

NEUROBIOLOGY OF AGING

卷:32

Article

Davatzikos, Christos¹  Bhatt, Priyanka¹  Shaw, Leslie M.²  Batmanghelich, Kayhan N.¹  Trojanowski, John Q.² 

[1] Univ Penn, Dept Radiol, Sect Biomed Image Anal, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

关键词: Alzheimer's disease;    Early detection;    Mild cognitive impairment;    MCI;    Pattern classification;    Imaging biomarkers;    CSF biomarkers;    SPARE-AD;   

DOI  :  10.1016/j.neurobiolaging.2010.05.023

来源: Elsevier

【 摘 要 】

Magnetic resonance imaging (MRI) patterns were examined together with cerebrospinal fluid (CSF) biomarkers in serial scans of Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with mild cognitive impairment (MCI). The SPARE-AD score, summarizing brain atrophy patterns, was tested as a predictor of short-term conversion to Alzheimer's disease (AD). MCI individuals that converted to AD (MCI-C) had mostly positive baseline SPARE-AD (Spatial Pattern of Abnormalities for Recognition of Early AD) and atrophy in temporal lobe gray matter (GM) and white matter (WM), posterior cingulate/precuneous, and insula. MCI individuals that converted to AD had mostly AD-like baseline CSF biomarkers. MCI nonconverters (MCI-NC) had mixed baseline SPARE-AD and CSF values, suggesting that some MCI-NC subjects may later convert. Those MCI-NC with most negative baseline SPARE-AD scores (normal brain structure) had significantly higher baseline Mini Mental State Examination (MMSE) scores (28.67) than others, and relatively low annual rate of Mini Mental State Examination decrease (-0.25). MCI-NC with midlevel baseline SPARE-AD displayed faster annual rates of SPARE-AD increase (indicating progressing atrophy). SPARE-AD and CSF combination improved prediction over individual values. In summary, both SPARE-AD and CSF biomarkers showed high baseline sensitivity, however, many MCI-NC had abnormal baseline SPARE-AD and CSF biomarkers. Longer follow-up will elucidate the specificity of baseline measurements. (C) 2011 Elsevier Inc. All rights reserved.

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