Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

NEUROBIOLOGY OF AGING

卷:34

Article

Thambisetty, Madhav¹  Beason-Held, Lori L.²  An, Yang²  Kraut, Michael³  Metter, Jeffrey⁴  Egan, Josephine⁵  Ferrucci, Luigi⁴  O'Brien, Richard⁶  Resnick, Susan M.² 

[1] NIA, Clin & Translat Neurosci Unit, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA

[2] NIA, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA

[3] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA

[4] NIA, Longitudinal Studies Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA

[5] NIA, Lab Clin Investigat, NIH, Baltimore, MD 21224 USA

[6] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

关键词: Insulin resistance;    Impaired glucose tolerance;    Brain function;    PET;    Cerebral blood flow;    Alzheimer's;    Aging;   

DOI  :  10.1016/j.neurobiolaging.2013.03.025

来源: Elsevier

【 摘 要 】

We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging underwent serial O-15-water positron emission tomography scans (age at first scan, 69.6 +/- 7.5 years) and oral glucose tolerance tests 12 years earlier (age at first oral glucose tolerance test, 57.2 +/- 11.1 years). Using voxel-based analysis, we compared changes in rCBF over an 8-year period between 15 participants with IGT in midlife and 49 with NGT. Significant differences were observed in longitudinal change in rCBF between the IGT and NGT groups. The predominant pattern was greater rCBF decline in the IGT group in the frontal, parietal, and temporal cortices. Some brain regions in the frontal and temporal cortices also showed greater longitudinal increments in rCBF in the IGT group. Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals. Published by Elsevier Inc.

【 授权许可】

Free