Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants

NEUROBIOLOGY OF AGING

卷:36

Article

Lehmann, Manja^1,2,3  Madison, Cindee²  Ghosh, Pia M.^1,2  Miller, Zachary A.¹  Greicius, Michael D.⁴  Kramer, Joel H.¹  Coppola, Giovanni⁵  Miller, Bruce L.¹  Jagust, William J.^1,2,6  Gorno-Tempini, Maria L.¹  Seeley, William W.¹  Rabinovici, Gil D.^1,2,6 

[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA

[2] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[3] UCL, Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat Dis, London WC1N 3BG, England

[4] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, FIND Lab, Stanford, CA 94305 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Dept Psychiat, Los Angeles, CA 90095 USA

[6] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA

关键词: Networks;    Intrinsic connectivity;    Functional magnetic resonance imaging;    Alzheimer's disease;    Posterior cortical atrophy;    Logopenic-variant primary progressive aphasia;   

DOI  :  10.1016/j.neurobiolaging.2015.06.029

来源: Elsevier

【 摘 要 】

The common and specific involvement of brain networks in clinical variants of Alzheimer's disease (AD) is not well understood. We performed task-free (resting-state) functional imaging in 60 nonfamilial AD patients, including 20 early-onset AD (age at onset <65 years, amnestic/dysexecutive deficits), 24 logopenic aphasia (language deficits), and 16 posterior cortical atrophy patients (visual deficits), as well as 60 healthy controls. Seed-based connectivity analyses were conducted to assess differences between groups in 3 default mode network (DMN) components (anterior, posterior, and ventral) and 4 additional non-DMN networks: left and right executive-control, language, and higher visual networks. Significant decreases in connectivity were found across AD variants compared with controls in the non-DMN networks. Within the DMN components, patients showed higher connectivity in the anterior DMN, in particular in logopenic aphasia. No significant differences were found for the posterior and ventral DMN. Our findings suggest that loss of functional connectivity is greatest in networks outside the DMN in early-onset and nonamnestic AD variants and may thus be a better biomarker in these patients. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

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