Evidence for a pervasive autobiographical memory impairment in

NEUROBIOLOGY OF AGING

卷:108

Article

Ramanan, Siddharth^1,2,3,4  Foxe, David^1,2,3  El-Omar, Hashim¹  Ahmed, Rebekah M.^1,5  Hodges, John R.^1,3,6  Piguet, Olivier^1,2,3  Irish, Muireann^1,2,3 

[1] Univ Sydney, Brain & Mind Ctr, 94 Mallett St, Sydney, NSW 2050, Australia

[2] Univ Sydney, Sch Psychol, Sydney, NSW, Australia

[3] ARC Ctr Excellence Cognit & Its Disorders, Sydney, NSW, Australia

[4] Univ Cambridge, MRC, Cognit & Brain Sci Unit, 15 Chaucer Rd, Cambridge, England

[5] Royal Prince Alfred Hosp, Dept Clin Neurosci, Memory & Cognit Clin, Sydney, NSW, Australia

[6] Univ Sydney, Sch Med Sci, Sydney, NSW, Australia

关键词: Alzheimer's disease;    Primary progressive aphasia;    Dementia;    Episodic memory;    Parietal;   

DOI  :  10.1016/j.neurobiolaging.2021.09.004

来源: Elsevier

【 摘 要 】

Although characterized primarily as a language disorder, mounting evidence indicates episodic amnesia in Logopenic Progressive Aphasia (LPA). Whether such memory disturbances extend to information encoded pre-disease onset remains unclear. To address this question, we examined autobiographical memory in 10 LPA patients, contrasted with 18 typical amnestic Alzheimer's disease and 16 healthy Control participants. A validated assessment, the Autobiographical Interview, was employed to explore autobiographical memory performance across the lifespan under free and probed recall conditions. Relative to Controls, LPA patients showed global impairments across all time periods for free recall, scoring at the same level as disease-matched cases of Alzheimer's disease. Importantly, these retrieval deficits persisted in LPA, even when structured probing was provided, and could not be explained by overall level of language disruption or amount of information generated during autobiographical narration. Autobiographical memory impairments in LPA related to gray matter intensity decrease in predominantly posterior parietal brain regions implicated in memory retrieval. Together, our results suggest that episodic memory disturbances may be an under-appreciated clinical feature of LPA. (c) 2021 Elsevier Inc. All rights reserved.

【 授权许可】

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