Impact of lifestyle dimensions on brain pathology and cognition

NEUROBIOLOGY OF AGING

卷:40

Article

Schreiber, Stefanie^1,2,3  Vogel, Jacob¹  Schwimmer, Henry D.¹  Marks, Shawn M.¹  Schreiber, Frank⁴  Jagust, William^1,5 

[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, 132 Barker Hall, Berkeley, CA 94720 USA

[2] Otto Von Guericke Univ, Dept Neurol, Magdeburg, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[4] Tech Univ Carolo Wilhelmina Braunschweig, Dept Control Engn, D-38106 Braunschweig, Germany

[5] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA

关键词: Aging;    Amyloid;    APOE;    Hippocampus;    PIB;   

DOI  :  10.1016/j.neurobiolaging.2016.01.012

来源: Elsevier

【 摘 要 】

Single lifestyle factors affect brain biomarkers and cognition. Here, we addressed the covariance of various lifestyle elements and investigated their impact on positron emission tomography-based beta-amyloid (A beta), hippocampal volume, and cognitive function in aged controls. Lower A beta burden was associated with a lifestyle comprising high cognitive engagement and low vascular risk, particularly in apolipoprotein E epsilon 4 carriers. Although cognitive function was related to high lifetime cognitive engagement and low vascular risk, A beta load had no relation to current cognitive function. The covariance between high adult socioeconomic status, high education, and low smoking prevalence predicted better cognitive function and this was mediated by larger hippocampal volume. Our data show that lifestyle is a complex construct composed of associated variables, some of which reflect factors operating over the life span and others which may be developmental. These factors affect brain health via different pathways, which may reinforce one another. Our findings moreover support the importance of an intellectually enriched lifestyle accompanied by vascular health on both cognition and presumed cerebral mediators of cognitive function. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free