Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology

NEUROBIOLOGY OF AGING

卷:33

Article

Kumar, Ashok¹  Rani, Asha¹  Tchigranova, Olga¹  Lee, Wei-Hua¹  Foster, Thomas C.¹ 

[1] Univ Florida, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA

关键词: Aging;    Enrichment;    Exercise;    Hippocampus;    Learning and memory;    Synaptic plasticity;    Afterhyperpolarization;    Cell excitability;   

DOI  :  10.1016/j.neurobiolaging.2011.06.023

来源: Elsevier

【 摘 要 】

Aged (20-22 months) male Fischer 344 rats were randomly assigned to sedentary (A-SED), environmentally-enriched (A-ENR), or exercise (A-EX) conditions. After 10-12 weeks of differential experience, the 3 groups of aged rats and young sedentary controls were tested for physical and cognitive function. Spatial discrimination learning and memory consolidation, tested on the water maze, were enhanced in environmentally-enriched compared with sedentary. A-EX exhibited improved and impaired performance on the cue and spatial task, respectively. Impaired spatial learning in A-EX was likely due to a bias in response selection associated with exercise training, as object recognition memory improved for A-EX rats. An examination of senescent hippocampal physiology revealed that enrichment and exercise reversed age-related changes in long-term depression (LTD) and long-term potentiation (LTP). Rats in the enrichment group exhibited an increase in cell excitability compared with the other 2 groups of aged animals. The results indicate that differential experience biased the selection of a spatial or a response strategy and factors common across the 2 conditions, such as increased hippocampal activity associated with locomotion, contribute to reversal of senescent synaptic plasticity. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

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