CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients

NEUROBIOLOGY OF AGING

卷:59

Article

Skillback, Tobias^1,2  Delsing, Louise^1,3  Synnergren, Jane³  Mattsson, Niklas^4,5  Janelidze, Shorena⁴  Nagga, Katarina⁴  Kilander, Lena⁶  Hicks, Ryan⁷  Wimo, Anders^8,9  Winblad, Bengt^9,10  Hansson, Oskar^4,5  Blennow, Kaj^1,2  Eriksdotter, Maria^10,11  Zetterberg, Henrik^1,2,12,13 

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Neurochem, Molndal, Sweden

[2] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[3] Univ Skovde, Sch Biosci, Syst Biol Res Ctr, Box 408, S-54128 Skovde, Sweden

[4] Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Malmo, Sweden

[5] Skane Univ Hosp, Dept Neurol, Lund, Sweden

[6] Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden

[7] AstraZeneca, IMED Biotech Unit, Discovery Sci, Molndal, Sweden

[8] Uppsala Univ, Cty Council Gavleborg, Ctr Res & Dev, Gavle, Sweden

[9] Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Div Neurogeriatr, Huddinge, Sweden

[10] Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden

[11] Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Huddinge, Sweden

[12] UCL Inst Neurol, Dept Mol Neurosci, London, England

[13] UCL, UK Dementia Res Inst, London, England

关键词: CSF/serum albumin ratio;    Dementia;    Blood-brain barrier;    Alzheimer's disease;   

DOI  :  10.1016/j.neurobiolaging.2017.06.028

来源: Elsevier

【 摘 要 】

A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362), Lewy body dementia (DLB, n = 50), frontotemporal dementia (FTD, n = 56), Parkinson's disease dementia (PDD, n = 23), other dementias (other, n = 48), and dementia not otherwise specified (NOS, n = 271). We compared CSF/serum albumin ratio to 2 healthy control groups (n = 292, n = 20), between dementia diagnoses, and tested biomarker associations. Patients in DLB, LAD, VaD, MIX, other, and NOS groups had higher CSF/serum albumin ratio than controls. CSF/serum albumin ratio correlated with CSF neurofilament light in LAD, MIX, VaD, and other groups but not with AD biomarkers. Our data show that BBB leakage is common in dementias. The lack of association between CSF/serum albumin ratio and AD biomarkers suggests that BBB dysfunction is not inherent to AD but might represent concomitant cerebrovascular pathology. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

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