Vascular brain lesions, brain atrophy, and cognitive decline. The Second Manifestations of ARTerial diseased-Magnetic Resonance (SMART-MR) study

NEUROBIOLOGY OF AGING

卷:35

Article

Kooistra, Minke¹  Geerlings, Mirjam I.¹  van der Graaf, Yolanda¹  Mali, Willem P. T. M.²  Vincken, Koen L.³  Kappelle, L. Jaap⁴  Muller, Majon^1,5  Biessels, Geert Jan⁴ 

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Radiol, NL-3508 GA Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Image Sci Inst, NL-3508 GA Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Dept Neurol, NL-3508 GA Utrecht, Netherlands

[5] VU Univ Med Ctr Amsterdam, Dept Internal Med, Amsterdam, Netherlands

关键词: Brain atrophy;    Vascular lesions;    Cognitive decline;    Vascular disease;    White matter lesions;    Brain infarcts;   

DOI  :  10.1016/j.neurobiolaging.2013.07.004

来源: Elsevier

【 摘 要 】

We examined the association between brain atrophy and vascular brain lesions (i.e., white matter lesions [WMLs] or brain infarcts), alone or in combination, with decline in memory and executive functioning over 4 years of follow-up in 448 patients (57 +/- 9.5 years) with symptomatic atherosclerotic disease from the Second Manifestations of ARTerial diseased-Magnetic Resonance SMART-MR study. Automated brain segmentation was used to quantify volumes of total brain, ventricles, cortical gray matter, and WMLs on 1.5-T magnetic resonance imaging (MRI). Brain infarcts were rated visually. WML volume was associated with significant decline in z score of executive functioning. No independent associations between MRI measures and memory decline were found. Significant declines in z scores of memory performance and of executive functioning were observed in patients with a combination of severe atrophy (upper quartile) and most vascular brain lesions (upper quartile) compared with those with minimal atrophy (lowest quartile) and fewest vascular brain lesions (lowest quartile). Our findings suggest that in patients with symptomatic atherosclerotic disease, the combination of brain atrophy and WMLs or brain infarcts accelerates cognitive decline over 4 years. (c) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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