Protective Mechanism of STAT3-siRNA on Cerebral Ischemia Injury

5th Annual International Conference on Material Science and Environmental Engineering

材料科学;生态环境科学

He, Jinting^1 ; Yang, Le^2 ; Liang, Wenzhao^1

Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun

130031, China^1

People's Hospital of Jilin Province, Changchun

130021, China^2

关键词: Biological functions;    Central nervous systems;    Cerebral ischemia;    Functional sites;    Intervention strategy;    Molecular mechanism;    Signal pathways;    Vascular lesions;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/301/1/012106/pdf
DOI  :  10.1088/1757-899X/301/1/012106

来源: IOP

【 摘 要 】

Nerve cells in ischemic brain injury will occur a series of complex signal transduction pathway changes and produce the corresponding biological function, thus affecting the central nervous system functionally different cells in the ischemic brain injury metabolism, division, Differentiation and death process, while changes in signal pathways also play an important role in the repair process of the post-ischemic nervous system. JAK/STAT pathway and vascular lesions have some relevance, but its exact mechanism after cerebral ischemia is not yet fully understood. This study is intended to further explore the JAK / STAT pathway in the functional site of STAT3 in neuronal ischemia Hypoxic injury and related molecular mechanisms, targeting these targets design intervention strategies to block the signal pathway, in order to provide a theoretical basis for the treatment of ischemic brain damage in this pathway.