Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1822

Article

Burns, Jeffrey M.¹  Honea, Robyn A.¹  Vidoni, Eric D.¹  Hutfles, Lewis J.¹  Brooks, William M.^1,2  Swerdlow, Russell H.¹ 

[1] Univ Kansas, Sch Med, Dept Neurol, Kansas City, KS 66160 USA

[2] Univ Kansas, Sch Med, Hoglund Brain Imaging Ctr, Kansas City, KS 66160 USA

关键词: Alzheimer disease;    Insulin;    Brain atrophy;    Cognitive decline;    Glucose tolerance test;   

DOI  :  10.1016/j.bbadis.2011.06.011

来源: Elsevier

【 摘 要 】

We assessed the relationship of insulin resistance with cognitive decline and brain atrophy over two years in early Alzheimer's disease (AD, n = 48) and nondemented controls (n = 61). Intravenous glucose tolerance tests were conducted at baseline to determine insulin area-under-the-curve (AUC). A standard battery of cognitive tasks and MRI were conducted at baseline and 2-year follow-up. In nondemented controls, higher baseline insulin AUC was associated with 2-year decline in global cognitive performance (beta = -0.36, p = 0.005). In early AD, however, higher insulin AUC was associated with less decline in global cognitive performance (beta = 0.26, p = 0.06), slower global brain atrophy (beta = 0.40, p = 0.01) and less regional atrophy in the bilateral hippocampi and cingulate cortices. While insulin resistance is associated with cognitive decline in nondemented aging, higher peripheral insulin may have AD-specific benefits or insulin signaling may be affected by systemic physiologic changes associated with AD. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

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