Distinct brain metabolic patterns separately associated with cognition, motor function, and aging in Parkinson's disease dementia

NEUROBIOLOGY OF AGING

卷:60

Article

Ko, Ji Hyun^1,2  Katako, Audrey^1,2  Aljuaid, Maram^1,2  Goertzen, Andrew L.³  Borys, Andrew⁴  Hobson, Douglas E.⁴  Kim, Seok Min⁵  Lee, Chong Sik^5,6 

[1] Univ Manitoba, Rady Fac Hlth Sci, Dept Human Anat & Cell Sci, Max Rady Coll Med, Winnipeg, MB, Canada

[2] Kleysen Inst Adv Med, Neurosci Res Program, Hlth Sci Ctr, Winnipeg, MB, Canada

[3] Univ Manitoba, Rady Fac Hlth Sci, Dept Radiol, Max Rady Coll Med, Winnipeg, MB, Canada

[4] Univ Manitoba, Max Rady Coll Med, Sect Neurol, Dept Internal Med,Rady Fac Hlth Sci, Winnipeg, MB, Canada

[5] Ulsan Univ, Inst Parkinsons Clin Res, Coll Med, Seoul, South Korea

[6] Asan Med Ctr, Dept Neurol, Seoul, South Korea

关键词: Parkinson's disease dementia;    PET;    FDG;    PIB;    FP-CIT;    Glucose metabolism;    Beta amyloid;    Dopamine transporter;    Multivariate analysis;    Network;    Dementia with Lewy bodies;    Alzheimer's disease;   

DOI  :  10.1016/j.neurobiolaging.2017.08.020

来源: Elsevier

【 摘 要 】

We explored whether patients with Parkinson's disease dementia (PDD) show a distinct spatial metabolic pattern that characterizes cognitive deficits in addition to motor dysfunction. Eighteen patients with PDD underwent 3 separate positron emission tomography sessions with [F-18] fluorodeoxyglucose (for glucose metabolism), fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (for dopamine transporter density) and Pittsburgh compound-B (for beta-amyloid load). We confirmed in PDD versus normal controls, overall hypometabolism in the posterior and prefrontal brain regions accompanied with hypermetabolism in subcortical structures and the cerebellar vermis. A multivariate network analysis then revealed 3 metabolic patterns that are separately associated with cognitive performance (p = 0.042), age (p = 0.042), and motor symptom severity (p = 0.039). The agerelated pattern's association with aging was replicated in healthy controls (p = 0.047) and patients with Alzheimer's disease (p = 0.002). The cognition-related pattern's association with cognitive performance was observed, with a trend-level of correlation, in patients with dementia with Lewy bodies (p = 0.084) but not in patients with Alzheimer's disease (p = 0.974). We found no association with fluorinated N-3fluoropropyl- 2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane and Pittsburgh compound-B positron emission tomography with patients' cognitive performance. (C) 2017 Elsevier Inc. All rights reserved.

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