Influence of ovarian stimulation for IVF/ICSI on the antioxidant defence system and relationship to outcome

REPRODUCTIVE BIOMEDICINE ONLINE

卷:29

Article

Palini, Simone¹  Benedetti, Serena²  Tagliamonte, Maria Chiara²  De Stefani, Silvia¹  Primiterra, Mariangela¹  Polli, Valeria¹  Rocchi, Patrizia¹  Catalani, Simona²  Battistelli, Serafina²  Canestrari, Franco²  Bulletti, Carlo¹ 

[1] Cervesi Hosp, Physiopathol Reprod Unit, Cattolica, Rimini, Italy

[2] Univ Urbino Carlo Bo, Dept Biomol Sci, Sect Clin Biochem & Cellular Biol, Urbino, Italy

关键词: antioxidant profile;    assisted reproduction;    follicular fluid;    ovarian stimulation;    oxidation stress;    pregnancy;   

DOI  :  10.1016/j.rbmo.2014.03.010

来源: Elsevier

【 摘 要 】

Ovarian stimulation is used with IVF/intracytoplasmic sperm injection (ICSI) cycles to obtain multiple oocytes and improve pregnancy rates; however, it also induces perturbation in the oxidant-antioxidant balance leading to oxidation stress. The present study monitored the plasma antioxidant status in women undergoing a long agonist protocol of ovarian stimulation at three different time points: at baseline (T0), after pituitary suppression (T1) and on the day of oocyte retrieval (T2). The antioxidant composition of follicular fluid samples collected on T2 was also evaluated. Significant decreases (P < 0.05) of plasma vitamin C, vitamin E and carotenoids were found between T1 and T2 but not between T0 and T1. At T2, high plasma vitamin E was associated with high numbers of total and mature oocytes retrieved per patient, which, in turn, were favourable for achieving pregnancy. Accordingly, women who became pregnant presented higher vitamin E concentrations both in plasma and FF than those who did not. In conclusion, this study confirmed the occurrence of significant modifications of the plasma antioxidant profile during ovarian stimulation with gonadotrophins; at the same time, it was found that both systemic and follicular antioxidant status may be related to IVF/ICSI outcome. (C) 2014, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free