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REPRODUCTIVE BIOMEDICINE ONLINE 卷:16
Anti-FSH antibodies associate with poor outcome of ovarian stimulation in IVF
Article
Haller, Kadri1,2  Salumets, Andres2,3  Uibo, Raivo1 
[1] Univ Tartu, Ctr Mol & Clin Med, Inst Gen & Mol Pathol, Dept Immunol, EE-50411 Tartu, Estonia
[2] Univ Tartu, Inst Mol & Cell Biol, Dept Biotechnol, Tartu, Estonia
[3] Ctr Infertil Treatment & Med Genet, Nova Vita Clin, Tartu, Estonia
关键词: anti-FSH antibodies;    follicular fluid;    IVF;    ovarian stimulation;   
DOI  :  10.1016/S1472-6483(10)60595-0
来源: Elsevier
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【 摘 要 】

FSH is required for spontaneous folliculogenesis and is widely used in ovarian stimulation in IVE Previously, increased concentrations of antibodies against FSH (anti-FSH) have been demonstrated in infertile women. This study aimed to: (i) assess the possible association of anti-FSH with an adverse outcome of IVF with regard to clinical parameters characterizing the ovarian reserve; and (ii) compare serum and follicular fluid (FF) anti-FSH concentrations in relation to follicle size and endocrine markers. IVF patients (n = 182) subjected to gonadotrophin-releasing hormone-antagonist protocol were assessed for anti-FSH using enzyme-linked immunosorbent assay. Increased concentrations of serum anti-FSH immunoglobulin (Ig)G and IgA were associated with impaired ovarian stimulation outcome, with cut-off values >1.0 arbitrary units predicting poor ovarian response (<= 3 oocytes) (adjusted odds ratio for IgG = 6.95, P = 0.005 and IgA = 3.60, P = 0.039). FF anti-FSH IgG and IgA were positively associated with serum anti-FSH concentrations and FSH concentration in FF. Additionally, FF anti-FSH IgG increased with follicle growth (linear regression coefficient = 0.02, P = 0.022). Collectively, these data suggest that serum anti-FSH antibodies are associated with poor ovarian response to FSH stimulation in IVF, with anti-FSH IgA and IgG potentially exerting a local FSH antagonizing effect in maturing follicles.

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