Computer-automated time-lapse analysis results correlate with embryo implantation and clinical pregnancy: A blinded, multi-centre study

REPRODUCTIVE BIOMEDICINE ONLINE

卷:29

Article

VerMilyea, Matthew D.¹  Tan, Lei²  Anthony, Joshua T.¹  Conaghan, Joe³  Ivani, Kristen⁴  Gvakharia, Marina⁵  Boostanfar, Robert⁶  Baker, Valerie L.⁷  Suraj, Vaishali²  Chen, Alice A.²  Mainigi, Monica¹  Coutifaris, Christos¹  Shen, Shehua² 

[1] Univ Penn, Penn Fertil Care, Philadelphia, PA 19104 USA

[2] Auxogyn Inc, Menlo Pk, CA 94025 USA

[3] Pacific Fertil Ctr, San Francisco, CA 94133 USA

[4] Reprod Sci Ctr Bay Area, San Ramon, CA 94583 USA

[5] Palo Alto Med Fdn Fertil, Fertil Physicians Northern Calif, San Jose, CA 95124 USA

[6] HRC Fertil, Encino, CA 91436 USA

[7] Stanford Fertil & Reprod Med Ctr, Palo Alto, CA 94304 USA

关键词: Eeva Test;    embryo selection;    implantation;    in-vitro fertilization;    pregnancy;    time-lapse;   

DOI  :  10.1016/j.rbmo.2014.09.005

来源: Elsevier

【 摘 要 】

Computer-automated time-lapse analysis has been shown to improve embryo selection by providing quantitative and objective information to supplement traditional morphology. In this multi-centre study, the relationship between such computer-derived outputs (High, Medium, Low scores), embryo implantation and clinical pregnancy were examined. Data were collected from six clinics, including 205 patients whose embryos were imaged by the Eeva (TM) System. The Eeva scores were blinded and not considered during embryo selection. Embryos with High and Medium scores had significantly higher implantation rates than those with Low scores (37% and 35% versus 15%; P < 0.0001; P = 0.0004). Similar trends in implantation rates were observed in different IVF centres each using their own protocols. Further analysis revealed that patients with at least one High embryo transferred had significantly higher clinical pregnancy rates than those with only Low embryos transferred (51% versus 34%; P = 0.02), although patients' clinical characteristics across groups were comparable. These data, together with previous research and clinical studies, confirm that computer-automated Eeva scores provide valuable information, which may improve the clinical outcome of IVF procedures and ultimately facilitate the trend of single embryo selection. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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