Computer-assisted embryo selection: a benefit in the evaluation of embryo quality?

REPRODUCTIVE BIOMEDICINE ONLINE

卷:23

Article

Paternot, Goedele¹  Debrock, Sophie¹  D'Hooghe, Thomas¹  Spiessens, Carl¹ 

[1] Leuven Univ Fertil Ctr, UZ Gasthuisberg, B-3000 Louvain, Belgium

关键词: computer-assisted scoring system;    embryo selection;    implantation;    live-birth rate;    single-embryo transfer;   

DOI  :  10.1016/j.rbmo.2011.05.007

来源: Elsevier

【 摘 要 】

Embryo selection is based on embryo developmental and morphological characteristics. Standard embryo evaluation has some disadvantages. New technology using multilevel images combined with a computer-assisted scoring system (CASS) has the potential to overcome these disadvantages. The aim of this study was to compare the value of a computer-assisted scoring system (CASS) versus a standard scoring system (SSS) in predicting implantation and live birth. This prospective study included 3185 embryos obtained during 502 IVF/intracytoplasmic sperm injection cycles with single-embryo transfer on day 3. Embryos were evaluated with two scoring systems: SSS and CASS. Logistic regression analyses were performed using implantation and live birth as outcomes. According to multiple regression analysis, implantation was influenced by number and size of blastomeres on day 3 using CASS and by all embryo parameters on day 3 using SSS. Combined analysis of both scoring systems revealed that implantation was affected by number and size of blastomeres using CASS and by the degree of embryo fragmentation using SSS. Using live birth as outcome, only the number of blastomeres on day 3, evaluated by SSS and CASS, was predictive. Prediction of implantation and live birth may be superior using CASS when compared with SSS. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free