Change in the Strategy of Embryo Selection with Time-Lapse System Implementation—Impact on Clinical Pregnancy Rates

Journal of Clinical Medicine

Patrick Saulnier¹  Pierre-Emmanuel Bouet²  Lisa Boucret³  Pascale May-Panloup³  Véronique Ferré-L’Hôtellier³  Léa Tramon³ 

[1] Department of Biostatistics and Methodology, Angers University Hospital, 49000 Angers, France;Department of Reproductive Medicine, Angers University Hospital, 49000 Angers, France;Reproductive Biology Unit, Angers University Hospital, 49000 Angers, France;

关键词: embryo selection;    time-lapse imaging;    morphokinetic assessment;    implantation;    clinical pregnancy rate;   

DOI  :  10.3390/jcm10184111

来源: DOAJ

【 摘 要 】

Time-lapse systems (TLS) and associated algorithms are interesting tools to improve embryo selection. This study aimed to evaluate how TLS and KIDScore™ algorithm changed our practices of embryo selection, as compared to a conventional morphological evaluation, and improved clinical pregnancy rates (CPR). In the study group (year 2020, n = 303 transfers), embryos were cultured in an EmbryoScope+ time-lapse incubator. A first team observed embryos conventionally once a day, while a second team selected the embryos for transfer based on time-lapse recordings. In the control group (year 2019, n = 279 transfers), embryos were selected using the conventional method, and CPR were recorded. In 2020, disagreement between TLS and the conventional method occurred in 32.1% of transfers, more often for early embryos (34.7%) than for blastocysts (20.5%). Irregular morphokinetic events (direct or reverse cleavage, multinucleation, abnormal pronuclei) were detected in 54.9% of the discordant embryos. When it was available, KIDScore™ was decreased for 73.2% of the deselected embryos. Discordant blastocysts mainly corresponded with a decrease in KIDScore™ (90.9%), whereas discordant Day 3 embryos resulted from a decreased KIDScore™ and/or an irregular morphokinetic event. CPR was significantly improved in the TLS group (2020), as compared to the conventional group (2019) (32.3% vs. 21.9%, p = 0.005), even after multivariate analysis. In conclusion, TLS is useful to highlight some embryo development abnormalities and identify embryos with the highest potential for pregnancy.

【 授权许可】

Unknown