The clinical benefit and safety of current and future assisted reproductive technology

REPRODUCTIVE BIOMEDICINE ONLINE

卷:25

Review

Brown, Rachel¹  Harper, Joyce^2,3 

[1] UCL, Div Med, London WC1E 6BT, England

[2] UCL, Inst Womens Hlth, UCL Ctr PG & D, London WC1E 6BT, England

[3] UCLH, Ctr Reprod & Genet Hlth, London, England

关键词: assisted reproductive technology;    embryo selection;    IVF;    preimplantation genetic screening;    sperm DNA damage;    time-lapse imaging;   

DOI  :  10.1016/j.rbmo.2012.04.009

来源: Elsevier

【 摘 要 】

Since the first birth by IVF was achieved in 1978, the techniques involved in assisted reproductive technology have grown at an enormous rate. However, new technology has rarely been robustly validated before clinical use and developing scientific understanding of the available techniques has done little to alter their use. Furthermore, there are inconsistencies in the available clinical studies and endpoints. The benefits of some technologies already established for routine use are currently dubious and there are clear ethical concerns with providing them to patients when their scientific basis is not clear. As the uptake of assisted reproductive technology increases and newer technologies continue to push the boundaries of science, it is important to consider the clinical benefits and safety of all assisted reproductive technologies. This review will discuss aspects of some of the more recent techniques, including sperm DNA-damage tests, intracytoplasmic morphologically selected sperm injection, amino acid and metabolomics profiling, preimplantation genetic screening and time-lapse imaging, and those that may have substantial impacts on the field of reproductive medicine in the future including artificial gametes, ovarian transplantation and gene therapy. RBMOnline (c) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free