Stability of AMH measurement in blood and avoidance of proteolytic changes

REPRODUCTIVE BIOMEDICINE ONLINE

卷:26

Article

Fleming, Richard¹  Fairbairn, Craig¹  Blaney, Catherine¹  Lucas, Dorothy¹  Gaudoin, Marco¹ 

[1] Glasgow Ctr Reprod Med, Glasgow G51 4FD, Lanark, Scotland

关键词: AMH;    anti-Mullerian hormone;    blood;    concentration;    serum;    stability;   

DOI  :  10.1016/j.rbmo.2012.11.005

来源: Elsevier

【 摘 要 】

The new Gen II assay for anti-Mullerian hormone (AMH) shows good stability and reliability in serum, but analyses of stability in whole blood are lacking. Testing the effects of storage of whole-blood samples at room temperature revealed significant increases in the measured value of AMH of 31% over 4 days (P < 0.001). The effect is temperature dependent, with storage at 4 degrees C showing markedly reduced increments. Further, samples collected into serum tubes with gel separators and centrifuged within 5 h (blood cells and serum physically separated within the collection tube) showed reliable stability over a period of more than 5 days. RBMOnline (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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