Anti-Mullerian hormone for the assessment of ovarian response in GnRH-antagonist-treated oocyte donors

REPRODUCTIVE BIOMEDICINE ONLINE

卷:24

Article

Polyzos, Nikolaos P.¹  Stoop, Dominic¹  Blockeel, Christophe¹  Adriaensen, Paul¹  Platteau, Peter¹  Anckaert, Ellen¹  Smitz, Johan¹  Devroey, Paul¹ 

[1] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Ctr Reprod Med, Brussels, Belgium

关键词: anti-Mullerian hormone;    AMH;    GnRH antagonist;    oocyte donation;    oocyte donors;    ovarian response;   

DOI  :  10.1016/j.rbmo.2012.01.024

来源: Elsevier

【 摘 要 】

Evidence regarding the role of anti-Mullerian hormone (AMH) among oocyte donors is limited and only involves gonadotrophin-releasing hormone (GnRH)-agonist-treated donors. This trial assessed the predictive ability of AMH for ovarian response among 108 oocyte donors treated with an antagonist protocol. In multivariate linear regression analysis, both AMH and age were independently associated with ovarian response (unstandardized coefficients 0.904 and -0.378, respectively). In receiver operating characteristic curve analysis, AMH performed better than age, but was a modest predictive marker for low (<= 6 oocytes) and excessive (> 20 oocytes) ovarian response (area under the curve (AUC) 0.643 and 0.695, respectively). Similarly, a multivariate logistic model including AMH and age was also modest (AUC 0.651 and 0.697 for low and excessive responders, respectively). The predictive ability of AMH did not significantly alter when different thresholds were adopted, such as < 4 oocytes for low response and > 25 for excessive response (AUC 0.759 and 0.724, respectively). Among oocyte donors treated with a GnRH-antagonist protocol, although AMH was correlated with the number of oocytes retrieved, it demonstrates a modest ability in discriminating women with low or excessive ovarian response. (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free