Limitations of a time-lapse blastocyst prediction model: a large multicentre outcome analysis

REPRODUCTIVE BIOMEDICINE ONLINE

卷:29

Editorial Material

Kirkegaard, Kirstine^1,2  Campbell, Alison³  Agerholm, Inge⁴  Bentin-Ley, Ursula⁵  Gabrielsen, Anette⁶  Kirk, John⁷  Sayed, Shabana⁸  Ingerslev, Hans Jakob^1,2 

[1] Aarhus Univ Hosp, Fertil Clin, DK-8200 Aarhus N, Denmark

[2] Aarhus Univ, DK-8000 Aarhus C, Denmark

[3] CARE Fertil Grp, Nottingham NG8 6PZ, England

[4] Braedstrup Hosp, Fertil Clin, DK-8740 Braedstrup, Denmark

[5] Dansk Fertilitetsklin, DK-2000 Frederiksberg, Denmark

[6] Ciconia Aarhus Privathosp, DK-8270 Hojbjerg, Denmark

[7] Maigaard Fertil Clin, DK-8200 Aarhus N, Denmark

[8] Klinikk Hausken, N-5531 Haugesund, Norway

关键词: assisted reproduction;    embryo selection;    prediction model;    time lapse;   

DOI  :  10.1016/j.rbmo.2014.04.011

来源: Elsevier

【 摘 要 】

The goal of embryo selection models is to select embryos with the highest reproductive potential, whilst minimizing the rejection of viable embryos. Ultimately, any embryo selection model must be tested on clinical outcome. We therefore retrospectively tested a published blastocyst prediction model on a large combined set of transferred embryos with known clinical outcome. The model was somewhat effective in that we found a relative increase of 30% for implantation in the model-selected group of embryos. There was, however, a concomitant large rejection of embryos from our test cohort, which actually resulted in pregnancy. This hypothetical experiment highlights the limitations of predicting blastulation only. Crucially, it illustrates that both sensitivity and specificity are important parameters when developing embryo selection models for prospective clinical use. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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