Anti-Mullerian hormone-based prediction model for a live birth in assisted reproduction

REPRODUCTIVE BIOMEDICINE ONLINE

卷:22

Article

La Marca, A.¹  Nelson, S. M.³  Sighinolfi, G.¹  Manno, M.⁴  Baraldi, E.¹  Roli, L.¹  Xella, S.¹  Marsella, T.¹  Tagliasacchi, D.¹  D'Amico, R.²  Volpe, A.¹ 

[1] Univ Modena & Reggio Emilia, Inst Obstet & Gynecol, Mother Infant Dept, I-41100 Modena, Italy

[2] Univ Modena & Reggio Emilia, Dept Oncol Hematol & Resp Dis, I-41100 Modena, Italy

[3] Univ Glasgow, Fac Med, Glasgow, Lanark, Scotland

[4] Pordenone Hosp, Maternal Paediat Dept, Pathophysiol Human Reprod & Sperm Bank Unit, Pordenone, Italy

关键词: AMH;    assisted reproduction;    live birth;    ovarian reserve;    prediction model;   

DOI  :  10.1016/j.rbmo.2010.11.005

来源: Elsevier

【 摘 要 】

Prediction of assisted reproduction treatment outcome has been the focus of clinical research for many years, with a variety of prognostic models describing the probability of an ongoing pregnancy or a live birth. This study assessed whether serum anti-Mullerian hormone (AMH) concentrations may be incorporated into a model to enhance the prediction of a live birth in women undergoing their first IVF cycle, by analysing a database containing clinical and laboratory information on IVF cycles carried out between 2005 and 2008 at the Mother-Infant Department of University Hospital, Modena. Logistic regression was used to examine the association of live birth with baseline patient characteristics. Only AMH and age were demonstrated in regression analysis to predict live birth, so a model solely based on these two criteria was generated. The model permitted the identification of live birth with a sensitivity of 79.2% and a specificity of only 44.2%. In the prediction of a live birth following IVF, a distinction, however moderate, can be made between couples with a good and a poor prognosis. The success of IVF was found to mainly depend on maternal age and serum AMH concentrations, one of the most relevant and valuable markers of ovarian reserve. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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