Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study

PSYCHIATRY RESEARCH

卷:252

Article

Hennebelle, Marie¹  Otoki, Yurika^1,2  Yang, Jun³  Hammock, Bruce D.³  Levitt, Anthony J.⁴  Taha, Ameer Y.¹  Swardfager, Walter^4,5 

[1] Univ Calif Davis, Coll Agr & Environm Sci, Dept Food Sci & Technol, Davis, CA 95616 USA

[2] Tohoku Univ, Grad Sch Agr Sci, Food & Biodynam Chem Lab, Sendai, Miyagi, Japan

[3] Univ Calif Davis, Coll Agr & Environm Sci, Dept Entomol & Hematol, Davis, CA 95616 USA

[4] Sunnybrook Res Inst, Hurvitz Brain Sci Program, Toronto, ON, Canada

[5] Univ Toronto, Dept Pharmacol & Toxicol, Room 4207,Med Sci Bldg,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada

关键词: Oxylipins;    Fatty acids;    Seasonal major depression;    Depression;    Soluble epoxide hydrolase;    Omega-3;    Omega-6;    Cytochrome p450;    Lipidomics;   

DOI  :  10.1016/j.psychres.2017.02.056

来源: Elsevier

【 摘 要 】

Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LCMS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9 +/- 4.4 to 19.9 +/- 7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s.

【 授权许可】

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