PSYCHIATRY RESEARCH | 卷:293 |
Impulsivity as a multifactorial construct and its relationship to PTSD severity and threat sensitivity | |
Article | |
Young, Dmitri A.1,2,3  Neylan, Thomas C.1,2,3  Zhang, Huaiyu3  O'Donovan, Aoife1,2,3  Inslicht, Sabra S.1,2,3  | |
[1] San Francisco VA Hlth Care Syst, 4150 Clement St,116P, San Francisco, CA 94121 USA | |
[2] Vet Hlth Res Inst, Northern Calif Inst Res & Educ NCIRE, 4150 Clement St, San Francisco, CA 94121 USA | |
[3] Univ Calif San Francisco, Weill Inst Neurosci, Dept Psychiat, San Francisco, CA 94143 USA | |
关键词: Impulsivity; PTSD; Posttraumatic stress disorder; Startle; Trauma; Biological markers; Psychophysiological response; | |
DOI : 10.1016/j.psychres.2020.113468 | |
来源: Elsevier | |
【 摘 要 】
Changes to the DSM-5's conceptualization of posttraumatic stress disorder (PTSD) highlight the importance of impulsivity within the context of PTSD-related arousal dysregulation. While the relationship between PTSD and threat sensitivity is well defined, how they relate to impulsivity remains understudied. We examined the relationship between PTSD symptom severity, threat sensitivity, and impulsivity. 124 participants completed the PTSD Checklist (PCL-C) and the Barratt Impulsiveness Scale 11th ed (BIS-11). BIS-11 items were separated to define cognitive and behavioral impulsivity subdomains. A trauma-exposed subsample of 39 participants were also exposed to no, ambiguous, and high threat conditions in a threat-enhanced acoustic startle paradigm with psychophysiological response as the outcome variable. PTSD severity was significantly associated with greater overall impulsivity and behavioral impulsivity. Greater overall impulsivity and both cognitive and behavioral impulsivity subdomains were significantly associated with psychophysiological magnitudes across threat conditions in the traumatized subsample. Our results suggest PTSD severity may linked to behavioral impulsivity and both cognitive and behavioral impulsivity are associated with threat sensitivity and hyperarousal. Assessing impulsivity within the context of PTSD, particularly in terms of its cognitive and behavioral subdomains, may provide important, clinically relevant information.
【 授权许可】
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