No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder

PSYCHIATRY RESEARCH

卷:259

Article

Snijders, Gijsje¹  Titulaer, Maarten J.²  Bergink, Veerle⁵  Bastiaansen, Anna E.²  Schreurs, Marco W. J.³  Ophoff, Roel A.^1,4  Boks, Marco P.¹  Kahn, Rene S.¹  de Witte, Lot D.¹ 

[1] UMC Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, POB 85500,Heidelberglaan 100, NL-3508 GA Utrecht, Netherlands

[2] Erasmus MC, Dept Neurol, Rotterdam, Netherlands

[3] Erasmus MC, Dept Immunol, Rotterdam, Netherlands

[4] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA 90024 USA

[5] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands

关键词: Bipolar disorder;    Autoimmune;    Mania;    Antibodies;    Encephalitis;    Immunology;   

DOI  :  10.1016/j.psychres.2017.10.043

来源: Elsevier

【 摘 要 】

A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.

【 授权许可】

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