Ultraselective Sorbents. Task 2: Molecularly Imprinted Polymers (MIPs)/Stabilized Antibody Fragments (STABs). Final Report FY 2004

Harvey, Scott D.

Pacific Northwest National Laboratory (U.S.)

关键词: Antibodies;    Polymers;    Synthesis;    Chemical Explosives;    Detection;   

DOI  :  10.2172/15016482
RP-ID  :  PNNL-14909
RP-ID  :  AC05-76RL01830
RP-ID  :  15016482

美国|英语

来源: UNT Digital Library

【 摘 要 】

This report describes the preparation and application of molecularly imprinted polymers (MIPs) for the highly selective analysis of target signature compounds. The overall goal of this project task is to exploit the high selectivity of MIPs to generate a pure and enriched fraction of target analyte from environmental samples, either during the sampling stage or immediately thereafter. Due to the high purity of analyte fraction obtained, simplified field portable instrumentation that is capable of high performance trace analysis can be constructed. Major sections contained in this FY 2004 Final Report describe: (1) the synthesis and evaluation of MIPs specific toward explosives, (2) the design, construction, and performance of a novel instrument for the trace aqueous analysis of G-series nerve agent hydrolysis compounds, and (3) interfacing MIP separations with ion mobility spectrometric detection.