Differences in the symptom profile of methamphetamine-related psychosis and primary psychotic disorders

PSYCHIATRY RESEARCH

卷:251

Article

McKetin, Rebecca^1,2,3  Baker, Amanda L.⁴  Dawe, Sharon⁵  Voce, Alexandra²  Lubman, Dan I.^6,7 

[1] Curtin Univ, Fac Hlth Sci, Natl Drug Res Inst, POB U1987, Perth, WA 6845, Australia

[2] Australian Natl Univ, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia

[3] Univ New South Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia

[4] Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW, Australia

[5] Griffith Univ, Sch Appl Psychol, Menzies Hlth Inst Queensland, Brisbane, Qld, Australia

[6] Eastern Hlth, Turning Point, Melbourne, Vic, Australia

[7] Monash Univ, Melbourne, Vic, Australia

关键词: Street drugs;    Central nervous system stimulants;    Amphetamine;    Amphetamine-related disorders;    Psychotic disorders;    Paranoia;    Hallucinations;   

DOI  :  10.1016/j.psychres.2017.02.028

来源: Elsevier

【 摘 要 】

We examined the lifetime experience of hallucinations and delusions associated with transient methamphetamine-related psychosis (MAP), persistent MAP and primary psychosis among a cohort of dependent methamphetamine users. Participants were classified as having (a) no current psychotic symptoms, (n=110); (b) psychotic symptoms only when using methamphetamine (transient MAP, n=85); (c) psychotic symptoms both when using methamphetamine and when abstaining from methamphetamine (persistent MAP, n=37), or (d) meeting DSM-IV criteria for lifetime schizophrenia or mania (primary psychosis, n=52). Current psychotic symptoms were classified as a score of 4 or more on any of the Brief Psychiatric Rating Scale items of suspiciousness, hallucinations or unusual thought content in the past month. Lifetime psychotic diagnoses and symptoms were assessed using the Composite International Diagnostic Interview. Transient MAP was associated with persecutory delusions and tactile hallucinations (compared to the no symptom group). Persistent MAP was additionally associated with delusions of reference, thought interference and complex auditory, visual, olfactory and tactile hallucinations, while primary psychosis was also associated with delusions of thought projection, erotomania and passivity. The presence of non-persecutory delusions and hallucinations across various modalities is a marker for persistent MAP or primary psychosis in people who use methamphetamine.

【 授权许可】

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