Correlates of transient versus persistent psychotic symptoms among dependent methamphetamine users

PSYCHIATRY RESEARCH

卷:238

Article

McKetin, Rebecca^1,2,3  Gardner, Jonathon²  Baker, Amanda L.⁴  Dawe, Sharon⁵  Ali, Robert⁶  Voce, Alexandra²  Leach, Liana S.²  Lubman, Dan I.^7,8 

[1] Curtin Univ, Fac Hlth Sci, Natl Drug Res Inst, POB U1987, Perth, WA 6845, Australia

[2] Australian Natl Univ, Ctr Res Ageing Hlth & Well Being, Canberra, ACT, Australia

[3] Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia

[4] Univ Newcastle, Prior Res Ctr Translat Neurosci & Mental Hlth, Callaghan, NSW 2308, Australia

[5] Griffith Univ, Menzies Hlth Inst Queensland, Sch Appl Psychol, Brisbane, Qld 4111, Australia

[6] Univ Adelaide, Adelaide, SA, Australia

[7] Eastern Hlth, Turning Point, Melbourne, Vic, Australia

[8] Monash Univ, Melbourne, Vic 3004, Australia

关键词: Street drugs;    Central nervous system stimulants;    Amphetamine;    Amphetamine-related disorders;    Psychotic disorders;    Paranoia;    Hallucinations;   

DOI  :  10.1016/j.psychres.2016.02.038

来源: Elsevier

【 摘 要 】

This study examined correlates of transient versus persistent psychotic symptoms among people dependent on methamphetamine. A longitudinal prospective cohort study of dependent methamphetamine users who did not meet DSM-IV criteria for lifetime schizophrenia or mania. Four non-contiguous one-month observation periods were used to identify participants who had a) no psychotic symptoms, (n=110); (b) psychotic symptoms only when using methamphetamine (transient psychotic symptoms, n=85); and, (c) psychotic symptoms both when using methamphetamine and when abstaining from methamphetamine (persistent psychotic symptoms, n=37). Psychotic symptoms were defined as a score of 4 or greater on any of the Brief Psychiatric Rating Scale items of suspiciousness, hallucinations or unusual thought content. Relative no psychotic symptoms, both transient and persistent psychotic symptoms were associated with childhood conduct disorder and comorbid anxiety disorders. Earlier onset methamphetamine use and being male were more specifically related to transient psychotic symptoms, while a family history of a primary psychotic disorder and comorbid major depression were specifically related to persistent psychotic symptoms. We conclude that there are overlapping but also distinct clinical correlates of transient versus persistent psychotic symptoms, suggesting potentially heterogeneous etiological pathways underpinning the psychotic phenomena seen amongst people who use methamphetamine. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free