The Federal Aviation Administration's Civil Aerospace Medical Institute conducts toxicological evaluation of postmortem biological samples collected from pilots involved in fatal civil aircraft accidents. The submitted samples are primarily analyzed for the presence of primary combustion gases, alcohol/volatiles, and drugs. Related to such an evaluation, findings of a unique aircraft accident are described in this report. Upon colliding with terrain in weather conditions of poor visibility, a 1-occupant airplane was substantially damaged, with no evidence of fire. Remains of the pilot were found outside the crashed aircraft. Pathological examination revealed multiple blunt force injuries and vascular congestion, including subdural hemorrhage of the cerebral cortex.